Paul Orchard, MD
Dr. Paul Orchard is the Medical Director of the Inherited Metabolic and Storage Disease Program and a Professor in the Department of Pediatrics, Division of Blood and Marrow Transplantation. Dr. Orchard's focus is in the use of hematopoietic stem cell transplantation and other cell therapies for inherited metabolic disorders, with a special interest in the inherited leukodystrophies, the mucopolysaccharidoses and osteopetrosis. His clinical research is in evolving new and combination therapies to decrease toxicity and improve outcomes, with a particular interest in the use of gene therapy approaches.
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Troy Lund, MD, PhD
Dr. Troy Lund is interested in the use of hematopoietic stem cell transplantation (HSCT) primarily for patients with inherited metabolic disorders, like Adrenoleukodystrophy (ALD), Hurler syndrome (MPS-1H), Hunter syndrome, Metachromatic Leukodystrophy, and others. He studies the onset of disease, biomarkers of disease, mechanism of disease, and how HSCT improves the disease process. His work both in his research laboratory and with his patients has created many new approaches to treatment, which will ultimately make HSCT safer and more effective.
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Ashish Gupta, MD
Dr. Gupta's primary interest focuses on early detection and developing effective cell and gene therapy interventions for children with inherited metabolic diseases. Current treatment strategies for these children include use of hematopoietic stem cell transplant as a means to either deliver enzymes as in lysosomal storage disorders or modify an uninhibited immune response as in cerebral adrenoleukodystrophy (ALD). He is also investigating autoimmune response of the host post hematopoietic stem cell transplant and ways to improve conditioning regimen and immune prophylaxis to control this effect, especially in children with inherited metabolic disorders. Additional research conducted by Dr. Gupta focuses on developing a registry and bio-specimen bank for patients with inherited metabolic diseases.
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Rebecca Tryon, Genetic Counselor
Rebecca Tryon, MS, MA, CGC is a licensed, certified genetic counselor. She obtained her Master of Science in genetic counseling from the University of Minnesota in 2013 and her Master of Arts in bioethics from the University of Minnesota in 2019. She has worked in various clinical setting including metabolism, general genetics, cardiology, pediatric oncology, and blood & marrow transplant. Her current clinical appointment primarily involves working with children and families with X-linked adrenoleukodystrophy, epidermolysis bullosa, Fanconi anemia, and disorders of telomere biology.
612-365-8100
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Danielle Jin, Research Coordinator
612-624-5994
[email protected]
